analysis; Brain

Metabolite Levels in Paediatric Brain Tumours Correlate with Histological Features.

Metabolite levels can be measured non-invasively using in vivo 1H magnetic resonance spectroscopy (MRS). These tumour metabolite profiles are highly characteristic for tumour type in childhood brain tumours; however, the relationship between …

A constrained least-squares approach to the automated quantitation of in vivo ¹H magnetic resonance spectroscopy data.

Totally Automatic Robust Quantitation in NMR (TARQUIN), a new method for the fully automatic analysis of short echo time in vivo (1)H Magnetic resonance spectroscopy is presented. Analysis is performed in the time domain using non-negative least …

A quantitative comparison of metabolite signals as detected by in vivo MRS with ex vivo 1H HR-MAS for childhood brain tumours.

(1)H MRS provides a powerful method for investigating tumour metabolism by allowing the measurement of metabolites in vivo. Recently, the technique of (1)H high-resolution magic angle spinning (HR-MAS) has been shown to produce high-quality data, …

An algorithm for the automated quantitation of metabolites in in vitro NMR signals.

The quantitation of metabolite concentrations from in vitro NMR spectra is hampered by the sensitivity of peak positions to experimental conditions. The quantitation methods currently available are generally labor intensive and cannot readily be …