chemistry

Influence of macromolecule baseline on (1) H MR spectroscopic imaging reproducibility.

Poorly characterized macromolecular (MM) and baseline artefacts are known to reduce metabolite quantitation accuracy in H MR spectroscopic imaging (MRSI). Increasing echo time (TE) and improvements in MM analysis schemes have both been proposed as …

Classification of single-voxel 1H spectra of childhood cerebellar tumors using LCModel and whole tissue representations.

In this study, mean tumor spectra are used as the basis functions in LCModel to create a direct classification tool for short echo time (1)H magnetic resonance spectroscopy of pediatric brain tumors. LCModel is a widely used analysis tool designed to …

The lipid composition of isolated cytoplasmic lipid droplets from a human cancer cell line, BE(2)M17.

(1)H nuclear magnetic resonance spectroscopy (NMR) resonances from lipids in tumours are associated with tumour grade and treatment response. The origin of these NMR signals is mainly considered to be cytoplasmic lipid droplets (LDs). Techniques …

The lipid composition of isolated cytoplasmic lipid droplets from a human cancer cell line, BE(2)M17.

(1)H nuclear magnetic resonance spectroscopy (NMR) resonances from lipids in tumours are associated with tumour grade and treatment response. The origin of these NMR signals is mainly considered to be cytoplasmic lipid droplets (LDs). Techniques …

¹H nuclear magnetic resonance spectroscopy characterisation of metabolic phenotypes in the medulloblastoma of the SMO transgenic mice.

Human medulloblastomas exhibit diverse molecular pathology. Aberrant hedgehog signalling is found in 20-30% of human medulloblastomas with largely unknown metabolic consequences. Transgenic mice over-expressing smoothened (SMO) receptor in granule …

A comparative study of feature extraction and blind source separation of independent component analysis (ICA) on childhood brain tumour 1H magnetic resonance spectra.

Independent component analysis (ICA) has the potential of determining automatically the metabolite signals which make up MR spectra. However, the reliability with which this is accomplished and the optimal approach for investigating in vivo MRS have …