methods

Short-acquisition-time JPRESS and its application to paediatric brain tumours.

To develop and assess a short-duration JPRESS protocol for detection of overlapping metabolite biomarkers and its application to paediatric brain tumours at 3 Tesla. The short-duration protocol (6 min) was optimised and compared for spectral quality …

Accurate classification of childhood brain tumours by in vivo ¹H MRS - a multi-centre study.

To evaluate the accuracy of single-voxel Magnetic Resonance Spectroscopy ((1)H MRS) as a non-invasive diagnostic aid for paediatric brain tumours in a multi-national study. Our hypotheses are (1) that automated classification based on (1)H MRS …

Ex-vivo HRMAS of adult brain tumours: metabolite quantification and assignment of tumour biomarkers.

High-resolution magic angle spinning (HRMAS) NMR spectroscopy allows detailed metabolic analysis of whole biopsy samples for investigating tumour biology and tumour classification. Accurate biochemical assignment of small molecule metabolites that …